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產(chǎn)品詳情

  • 產(chǎn)品名稱：5HT2C Receptor Blocking Peptide peptide (STJ505510)

  • 產(chǎn)品型號(hào)：STJ505510-250
  • 產(chǎn)品廠商：ST john's laboratory
  • 產(chǎn)品文檔：
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簡(jiǎn)單介紹：
5HT2C Receptor Blocking Peptide peptide (STJ505510)
詳情介紹：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: 5HT2C Receptor Blocking Peptide is synthetically produced from the 400-458 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: HTR2C
Gene ID: 3358
Uniprot ID: 5HT2C_HUMAN
Immunogen Region: 400-458
Immunogen: Synthetic peptide taken within amino acid region 400-458 on human 5-hydroxytryptamine receptor 2C.
Tissue Specificity Detected in brain.
Post Translational Modifications N-glycosylated.
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.
Peptide Name 5-Hydroxytryptamine Receptor 2c
5-Ht-2c
5-Ht2c
5-Htr2c
5-Hydroxytryptamine Receptor 1c
5-Ht-1c
5-Ht1c
Serotonin Receptor 2c
Database Links Reactome: R-HSA-390666
Reactome: R-HSA-416476
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Peptide Names 5-Hydroxytryptamine Receptor 2c protein
5-Ht-2c protein
5-Ht2c protein
5-Htr2c protein
5-Hydroxytryptamine Receptor 1c protein
5-Ht-1c protein
5-Ht1c protein
Serotonin Receptor 2c protein
HTR2C protein
HTR1C protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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